National Institute on Aging (NIA) – Alzheimer's Association Guideline on Neuropathologic Assessment of Alzheimer's During an Autopsy. These criteria provide guidance for documenting and reporting Alzheimer's-related brain changes observed during an autopsy. Key recommendations include ranking the severity of Alzheimer's pathology based on three hallmark changes; reporting these rankings as "Alzheimer's disease neuropathologic changes" whether or not the person was ever diagnosed with Alzheimer's during life, with a goal of understanding the full range of brain changes that may occur in people with or without Alzheimer's symptoms; and including assessment of Lewy bodies, vascular abnormalities and other brain changes that commonly coexist with Alzheimer's hallmarks.
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